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Research Article
Interventional Therapy in Diabetic Foot: Risk Factors, Clinical Events and Prognosis at One Year Follow-up (A Study of 103 Cases)

Marco Matteo Ciccone, Alfredo Marchese, Aikaterini Generali, Cataldo Loiodice, Francesca Cortese, Rosa Carbonara, Pietro Scicchitano, Luigi Laviola and Francesco Giorgino

Pakistan Journal of Biological Sciences, 2012, 15(16), 789-794.


Diabetic foot is a common complication in diabetes mellitus course, able to increase the overall morbidity/mortality risk of such a disease. The aim was to investigate the outcomes, the incidence of clinical events, the number of recurrent ulcers in patients with diabetic foot during 1 year follow-up after angioplasty (PTA) revascularization. From January 2007 to August 2009, 103 diabetic patients with diabetic foot undergoing revascularization of a lower limb by PTA were recruited. At 1 year follow-up we assessed: “major” (death, stroke, Myocardial Infaction (MI) and “minor” (Deep Vein Thrombosis (DVT), renal failure, restenosis) events incidence; recurrent ulcers incidence; the predictive elements of all these events. At 1 year follow-up, “major”/“minor” events incidence was 15% (deaths:5, stroke:1, MI: 9%) and 34% (renal failure: 11, DVT: 9, restenosis: 14%), respectively. Obesity, high low density level-cholesterol levels and distal arterial lesions (at posterior tibial artery in particular) were statistically significantly associated with major events (p<0.05); only obesity resulted statistically associated with minors (p = 0.043). High levels of C-reactive protein had a statistically significant relationship with the recurrence of ulcers (p = 0.006) while distal arterial obstructions showed a trend toward significance. To improve diabetic foot mortality and morbidity rate, our study underlines the importance of a prompt diagnosis and appropriate revascularization treatment. Other studies are needed to ascertain these.

ASCI-ID: 1-5827

Cited References Fulltext

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