Research Article
Hepatoprotective Activity of Silybum marianum and Cichorium intybus Against Thioacetamide in Rat

H. Madani, M. Talebolhosseini, S. Asgary and G.H. Naderi

Pakistan Journal of Nutrition, 2008, 7(1), 172-176.

Abstract

The plant phenolic compounds such as flavonoids have an important role in the treatment of many diseases and some of them have a potent hepatoprotective effect. In this study, we have investigated the protective effects of polyphenolic extracts of Silybum marianum and Cichorium intybus on thioacethamide-induced hepatotoxicity in rat. The extracts were injected to the rats, at a dosis of 25 mg kg-1 body weight together whit thioacetamide at a dosis of 50 mg kg-1 body weight. To assess the affectivity of extracts, against thioacetamide, the activity of aminotransferases (SGOT and SGPT), alkalin phosphatase, bilirubin, Na+ and K+ were measured. Significant decrease in the activity of aminotransferases, alkalin phosphatase and bilirubin was observed in the groups treated with extracts and thioacetamide compared with the group that was treated only with thioacetamide. The level of Na+, K+ and liver weight between different groups was not significantly altered. This results prove the protective effect of extracts on liver cells. The protective effects of this extracts can be due to the presence of flavonoids compounds and their antioxidant effects.

ASCI-ID: 100-590

Cited References Fulltext

Similar Articles


The Effect of Oxidized Fat Added to Feed Mixture on Selected Quality Attributes of Turkey Meat

Pakistan Journal of Nutrition, 2004, 3(4), 213-221.

Trace Elements and Anti - Oxidant Status in Gravid BALB/c Mice Infected with Plasmodium yoelii Malaria Parasites at Different Gestational Periods

Pakistan Journal of Nutrition, 2008, 7(6), 757-762.

Evaluation of Fat and Vitamin E in Some Cookies Diet

Pakistan Journal of Nutrition, 2009, 8(3), 214-217.

The Relationship Between the Antioxidants Intake and Blood Indices of the Children with Thalassemia in Sabzevar and Mashhad

Pakistan Journal of Nutrition, 2010, 9(7), 716-719.

Influence of CaCl2 on Biochemical Composition, Antioxidant and Enzymatic Activity of Apricot at Ambient Storage

Pakistan Journal of Nutrition, 2013, 12(5), 476-483.

Natural Antioxidants Effect of Mulberry Fruits (Morus nigra and Morus alba L.) On Lipids Profile and Oxidative Stress in Hypercholestrolemic Rats

Pakistan Journal of Nutrition, 2013, 12(7), 665-672.

Antioxidative Activities of Aqueous and Ethanolic Extracts of Licorice Roots

Pakistan Journal of Nutrition, 2014, 13(5), 267-270.

Antioxidant and Antimicrobial Potential of Locally Sun Dried Garlic and Ginger Powder Available in District Layyah, Punjab, Pakistan

Pakistan Journal of Nutrition, 2014, 13(11), 642-647.

Enhancing Secondary Metabolites (Emphasis on Phenolics and Antioxidants) in Plants through Elicitation and Metabolomics

Pakistan Journal of Nutrition, 2018, 17(9), 411-420.

Antioxidant Activities of Beetroot (Beta vulgaris L.) Extracts

Pakistan Journal of Nutrition, 2018, 17(10), 500-505.

Functional Yogurt Fortified with Phenolic Compounds Extracted from Strawberry Press Residues and Fermented with Probiotic Lactic Acid Bacteria

Pakistan Journal of Nutrition, 2019, 18(6), 530-537.

Phytochemical Screening and Pharmacological Activities of the Ethanolic Stem Extract of Cleome gynandra

Pakistan Journal of Nutrition, 2020, 19(4), 153-159.

Antioxidant and Antihyperlipidemic Properties of Different Granulometric Classes of Adansonia digitata Pulp Powder

Pakistan Journal of Nutrition, 2020, 19(8), 393-403.

The Hepatoprotective Effect of Vitamin C and E on Hepatotoxicity Induced by Ethanol in Sprague Dawley Rats

Pakistan Journal of Nutrition, 2006, 5(6), 507-511.

Hepatoprotective Activity of Desert Truffle (Terfezia claveryi) in Comparison with the Effect of Nigella sativa in the Rat

Pakistan Journal of Nutrition, 2010, 9(1), 52-56.

Hepatoprotective Effect of Dill (Anethum graveolens L.) and Fennel (Foeniculum vulgare) Oil on Hepatotoxic Rats

Pakistan Journal of Nutrition, 2014, 13(6), 303-309.