Total synthesis of (–)-renieramycin G from L-tyrosine

Research Article
Total synthesis of (–)-renieramycin G from L-tyrosine

Xiang Wei Liao, Wei Liu, Wen Fang Dong, Bao He Guan, Shi Zhi Chen and Zhan Zhu Liu

Tetrahedron, 2009, 65(29), 5709-5715. DOI: 10.1016/j.tet.2009.05.025

Abstract

(–)-Renieramycin G was synthesized in 21 steps for the longest linear sequences employing L-tyrosine methyl ester as the chiral starting material in 8.5% overall yield. Two of the four chiral centers came from l-tyrosine methyl ester, and the other two were induced through an intermolecular and an intramolecular Pictet&150;Spengler reaction, respectively.

ASCI-ID: 471-33