Search. Read. Cite.

Easy to search. Easy to read. Easy to cite with credible sources.

Research Article
Preliminary Clinical Assessment of a Gentamicin-Loaded Monoolein Gel Intended to Treat Chronic Osteomyelitis

Moustapha Ouedraogo, Christophe S. Da, Innocent S. Nacoulma, Hamado Kafando, Rasmane Semde, Issa T. Some, Rasmata Ouedraogo, Innocent P. Guissou, Brigitte Evrard, Viviane Henschel, Jacques Dubois and Karim Amighi

Trends in Medical Research, 2008, 3(2), 82-89.

Abstract

The aim of this current study was to perform a preliminary clinical assessment of efficacy and safety of a biodegradable gentamicin-loaded monoolein gel. An open single dose, one treatment study including 19 patients with chronic osteomyelitis caused by a microorganism sensitive to gentamicin was conducted. After surgical curettage of the infected bone, the dead space was filled in with the gentamicin-loaded monoolein gel. To prevent post-operative septicaemia, a systemic antibiotherapy was prescribed for 3 days following the operation. Clinical, biological and radiological follow-up was performed to assess the efficacy and the safety of the treatment. After a follow-up period ranging from 2 to 12 months, all 19 patients included in the study felt well. Eighteen patients recovered from chronic osteomyelitis without adverse events. The wound of one patient whose bone was exposed did not scar over after 10 months. However, it was no longer infected. In conclusion, gentamicin-loaded monoolein gel was efficacious in treating chronic osteomyelitis without side-effects.

ASCI-ID: 96-2

Cited References Fulltext

Related Articles


A Logarithmic Spiral Function to Plot a Cochleaogram

Trends in Medical Research, 2008, 3(1), 36-40.

Cited By


Development and evaluation of liquid embolic agents based on liquid crystalline material of glyceryl monooleate

International Journal of Pharmaceutics, 2014, (), . DOI: 10.1016/j.ijpharm.2014.05.036

Numerical simulation of mid-rise concrete shear walls reinforced with GFRP bars subjected to lateral displacement reversals

Engineering Structures, 2014, 73(), 62. DOI: 10.1016/j.engstruct.2014.04.050

Multimatrix measurement of persistent organic pollutants in Mar Chiquita, a continental saline shallow lake

Science of The Total Environment, 2014, 490(), 73. DOI: 10.1016/j.scitotenv.2014.04.114

A qualitative risk assessment of the microbiological risks to consumers from the production and consumption of uneviscerated and eviscerated small game birds in the UK

Food Control, 2014, 45(), 127. DOI: 10.1016/j.foodcont.2014.04.040

Genotypic variation of zinc and selenium concentration in grains of Brazilian wheat lines

Plant Science, 2014, 224(), 27. DOI: 10.1016/j.plantsci.2014.03.022

Functional protein from cumin seed (Cuminum cyminum): Optimization and characterization studies

Food Hydrocolloids, 2014, 41(), 178. DOI: 10.1016/j.foodhyd.2014.04.017

Molecular vibrational dynamics of rhodamine B dye in solution studied by femtosecond CARS

Vibrational Spectroscopy, 2014, 73(), 24. DOI: 10.1016/j.vibspec.2014.04.001

Review on pre- and post-harvest management of peanuts to minimize aflatoxin contamination

Food Research International, 2014, 62(), 11. DOI: 10.1016/j.foodres.2014.02.023

Identification and characterization of papain-generated antioxidant peptides from palm kernel cake proteins

Food Research International, 2014, 62(), 726. DOI: 10.1016/j.foodres.2014.04.041

Principles, developments and applications of computer vision for external quality inspection of fruits and vegetables: A review

Food Research International, 2014, 62(), 326. DOI: 10.1016/j.foodres.2014.03.012

Strong seed-bank effects in bacterial evolution

Journal of Theoretical Biology, 2014, 356(), 62. DOI: 10.1016/j.jtbi.2014.04.009

Electrical and optical properties of nanostructured indium doped zinc oxide thin films deposited by ultrasonic chemical spray technique, starting from zinc acetylacetonate and indium chloride

Materials Science in Semiconductor Processing, 2014, 26(), 288. DOI: 10.1016/j.mssp.2014.05.011

The genus Inula and their metabolites: From ethnopharmacological to medicinal uses

Journal of Ethnopharmacology, 2014, 154(2), 286. DOI: 10.1016/j.jep.2014.04.010

Characterization of Siahmazgi cheese, an Iranian ewe's milk variety: Assessment of physico-chemical, textural and rheological specifications during ripening

LWT - Food Science and Technology, 2014, 58(2), 335. DOI: 10.1016/j.lwt.2013.06.002

Enhanced chemical stability, chromatic properties and regeneration of betalains in Rivina humilis L. berry juice

LWT - Food Science and Technology, 2014, 58(2), 649. DOI: 10.1016/j.lwt.2014.03.027

Yang-tonifying traditional Chinese medicinal plants and their potential phytoandrogenic activity

Chinese Journal of Natural Medicines, 2014, 12(5), 321. DOI: 10.1016/S1875-5364(14)60040-6

Antibacterial activity of essential oils, their blends and mixtures of their main constituents against some strains supporting livestock mastitis

Fitoterapia, 2014, 96(), 1. DOI: 10.1016/j.fitote.2014.04.003

Threats and opportunities of plant pathogenic bacteria

Biotechnology Advances, 2014, 32(1), 215. DOI: 10.1016/j.biotechadv.2013.11.001

Psychological treatment of generalized anxiety disorder: A meta-analysis

Clinical Psychology Review, 2014, 34(2), 130. DOI: 10.1016/j.cpr.2014.01.002

Physiological relationship between oil tolerance and flooding tolerance in marsh plants

Environmental and Experimental Botany, 2014, (), . DOI: 10.1016/j.envexpbot.2014.05.003