Identification of Novel Toxicity-associated Metabolites by Metabolomics and Mass Isotopomer Analysis of Acetaminophen Metabolism in Wild-type and Cyp2e1-null Mice

Chi Chen, Kristopher W. Krausz, Jeffrey R. Idle and Frank J. Gonzalez

The Journal of Biological Chemistry 283 ( 8 ): 4543 - 4559 , 2008