S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2

Jin Zhang, Zhanguo Gao, Jun Yin, Michael J. Quon and Jianping Ye

The Journal of Biological Chemistry 283 ( 51 ): 35375 - 35382 , 2008