Therapeutic Gene Silencing Delivered by a Chemically Modified Small Interfering RNA against Mutant SOD1 Slows Amyotrophic Lateral Sclerosis Progression

Hongyan Wang, Animesh Ghosh, Huricha Baigude, Chao-shun Yang, Linghua Qiu, Xugang Xia, Hongxia Zhou, Tariq M. Rana and Zuoshang Xu

The Journal of Biological Chemistry 283 ( 23 ): 15845 - 15852 , 2008