Synthesis and Antimicrobial Activities of Some 3,4-Dihydroquinazolinone-4-One, Quinoxaline, Benzoxazine, Benzothiazine, Pyran and Pyrrolidinedione Derivatives

Research Article
Synthesis and Antimicrobial Activities of Some 3,4-Dihydroquinazolinone-4-One, Quinoxaline, Benzoxazine, Benzothiazine, Pyran and Pyrrolidinedione Derivatives

Nagwa M. Fawzy, Samira A. Swelam and Mohamed A. Farid

Biotechnology, 2008, 7(1), 43-50.

Abstract

Synthesis of some 3,4-dihydroquinazolinone-4-one, quinoxaline, benzoxazine, benzothiazine, pyran and pyrrolidinedione derivatives using readily available starting materials were described. It has been found that compounds 4b, 8a and 8b were the most active compounds against the test organisms. Compound 8b was the most active against Gram positive and Gram negative bacteria (B. subtilus and E. coli) where compounds 4b and 8a were active against (St. aureus). Compound 12a is the least active member of this group. On the other hand, compound 14b showed a good activity compound against St. aureus.

ASCI-ID: 11-365

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