Evolution toward Small Molecule Inhibitor Resistance Affects Native Enzyme Function and Stability, Generating Acarbose-insensitive Cyclodextrin Glucanotransferase Variants

Ronan M. Kelly, Hans Leemhuis, Linda Gatjen and Lubbert Dijkhuizen

The Journal of Biological Chemistry 283 ( 16 ): 10727 - 10734 , 2008